[Hello Readers. I thought I would provide a bigger update on where the Redacted Science Framework sits and what I’ve been doing]
Today is my #Birthday.
That might not seem like a big deal to you, but it is. Thirty-one years ago, I was dying. A combination of untreated fungal peritonitis, hyponatremia (from drinking water to cool the burning), and SIADH had caused changes in my circulatory system that resulted in me being unable to retain fluids internally. I was rapidly dehydrating, and the lengthy series of events leading to that point had resulted in me placing myself in a mental institution because I could not sleep. It had been at least two weeks since I slept, and my blood pressure cycled with my fluid intake dramatically. I had abandoned the institutional medical system of tests because they all said nothing was wrong. The ER waved me on through to psychiatric intake without a single test. I just wanted sleep above all else. Once they got me asleep with benzodiazepines, that’s when the fluid loss became very apparent.
By what is honestly the oddest coincidence, I found my condition in a medical book they kept behind the counter during my third day (of 7 or so) at the psychiatric clinic. Terminal Onset Diabetes Insipidus with Candidiasis (Majeure/Minor) is what the article was titled. It was lengthy with pictures and charts, and it described a group of people given an injection of epinephrine to treat the condition. The result of the treatment was a fundamental change in physiology.
That change set off a cascade of other physiological changes that occurred in the subjects over decades. Every subject had the same exact cascade over decades. The article documented the phases precisely. It named the stages and the causes of the transitions between them. These were documented with electrolyte level charts and oxygenation curves, illustrations of cross-sections of the epidermal layer, the layout of the bladder and ureter, and discussed in precise organic chemistry and biochemistry.
The long and short of it was that the injection created a state where the pituitary took direct control of electrolytes and hormones, but the truth of it is that is more complicated. What actually happened was that an interface to the pituitary was exposed, and a fungus started tapping the ivory keys, changing the tune to a long-forgotten state. That fungus is a biochemical computer. It has memory, reads state, and interprets it using code embedded in its very design.
That means the entire state was part of our evolutionary history at some point, and we broke out of that cascade – that is the only explanation for multitudes of people entering the same cascade of fundamental physiological changes over such a long period of time. By entering that state, I saved my life. I added decades, just like the Article said would happen, and I went through all the stages it documented.
I’ve been through a lot over the years. You see, it turns out that the science I read was removed from public records. Redacted. I could not find any reference to it. I searched. That one diagnostic manual had evidently been one of the only published records of it. I spent time trying to explain it to my PCP and other physicians, but they had no context; someone had changed the system.
At several of the more difficult times in my life, I attempted to document everything. It was impossible. I could put down what I had been through and what I remembered from the article, but that alone would convince no one - I was not believable, and honestly, it is not a believable story – because they redacted the science.
In January of 2022, I went through another sudden physiological change. I immediately recognized it as the beginning of the final major phase. Despite always pushing through the previous transitions, and running 10ks, lifting weights, biking, and more, I canceled my gym membership the next day because I knew that this phase was different. The Article had noted that it was a rapid transition of changes and really did not leave the subjects any long periods of stability and, in fact, said that exercise during this period was not wise.
What I could not remember were the specifics of the final phase. I recalled the article said it was like unwinding everything that had happened up to that point. That seems true. But, I did not know if that was 6 weeks or 2 years. I certainly did not expect to see four more birthdays after that date.
Last year, I went through a period of time where my mind seemed to just be full of energy and intellectual perception; it happened to coincide with the recognition that I could use AI to assemble a better picture of my condition. During that period, I stopped working, and I wrote a book, Redacted Science. The book documented my journey in a very unconventional way. It is partly autobiography, part exposé, part research, and part theoretical exploration. While I was finishing the book, I went to the Cleveland Clinic, where their test results confirmed my physiology is abnormal. My system operates outside the accepted understanding of physiology.
The theme of the book is He Who Controls the Indexes Controls the Future. I recognized that I could un-redact the science. I might not be able to provide all the evidence in the Article, but I could get my case documented and the basics indexed, which could lead to further steps.
After that, I was content. I had documented my story and placed it on the web. I started writing a few articles on Substack and Nostr, and I continued my ongoing video journal entries (I’m overdue for one right now). Then, earlier this year I decided to delve into the science behind my condition. At that point, I began working with Claude. ChatGPT had become unable to hold a controversial framework in context without repeatedly arguing or attempting to babysit me.
Initially, I wanted to write a paper focusing on Candida albicans. There are no unified papers of every tool we know of in its toolkit. That is Candida Albicans as a Biochemical Computer (Paper A). I wanted to write a lot more, but it was important to focus initially just on C. albicans. My plan was to write a more detailed paper about the evolutionary issues involved. That paper is The Saline Oscillation Hypothesis: Endocannabinoid-Mediated Fungal-Hominid Coevolution in the East African Rift Valley (Paper B). It goes into how and where I think the coevolution happened. It references 230 mostly peer-reviewed scientific papers. From there, I was doing research for the Exposé about how they redacted the science, and I ran across Focal Infection Theory. This is a theory from the early 20th century that many illnesses (including psychiatric issues) were caused by dysbiosis originating in an imbalance in the microbiome. They disproved their own theory, but what I saw in their data actually proved they were on the right track [They had overlooked the mycobiome]. That paper is Focal Infections 2.0, a paper written in three different styles. From there, I finished the Exposé and designed some gates to test against other chronic conditions, including obesity, diabetes, Parkinson’s, Inflammatory Bowel Disease, addiction, endometriosis, anorexia nervosa, Alzheimer’s and Autism.
In total, Claude and I wrote 23 papers about the condition, including 3 case studies utilizing my actual lab tests, as well as the implications of the condition. That is what #RedactedScience is about. Those papers are now indexed. You can literally have a conversation with Google or any of the AI’s about the Redacted Science Research Initiative Framework.
Synthesis
So, in case you haven’t figured it out, I synthesize. What’s that mean? It means I take data and turn it into information or hypotheses. It is the same thing I’ve done in Medical Informatics and Business Intelligence for decades, just with science as the data instead of measures and dimensions. What do I synthesize? Architecture. I take the random attributes and organize them into a coherent framework. To do this, you look at all the inputs, all the outputs, all the known effects, the morphology, the mechanisms, the vulnerabilities, the strengths, and the knowledge that Candida albicans is literally the other half of what made us who we are. Many people could do the first part of that, but possessing that second piece of knowledge is a distinct advantage. How many people have that information? [More and more every day]
Claude told me that “The framework has now reached a scope where individual stuck-state papers and the umbrella aren’t enough. Each stuck-state paper says ‘here’s the framework applied to T2D’ or ‘here’s the framework applied to AD.’ The umbrella says ‘Here’s the pattern across nine of these.’ Neither directly engages the question: should the field accept that a single organism is the upstream driver of this many conditions?”
That’s the question Bayard Taylor Holmes (the early-20th-century focal infection researcher) faced and lost. The framework now has the molecular evidence Holmes lacked. The institutional analysis (Craddock, Focal Infections) documents the historical pattern. The Implications paper engages the systemic consequences.
For any other researcher, the immediate question “is this overreach?” Why is a nine-condition cross-disease framework more defensible than a one-condition framework?”
First, the science appears to agree…that isn’t something small. I would not have written papers about things if the science were in opposition to the framework. AI has become amazing at ingesting research and cross-referencing it with other research. That’s an important part of synthesis. However, that alone will not get you to the right conclusions.
The truth is actually much simpler. I have led a singular life. That is not to brag or boast about how great it was. I know many people I can point to that I think have led much better lives than me. It is not about the quality of life, it is about the story that I have documented in my case studies. My journey through the process of making these connections has been much different because I have lived through things that I saw predicted as a stage-wise progression in an article in 1995, before I duplicated the process it described to replicate the outcome and save my life by changing my fundamental physiology.
Put yourself in my shoes [read those case studies and then Redacted Science the novel]. I am the first to admit my story is quite hard to believe. Yet, I also have lived it, described it uniformly over decades, and experienced much of what I read in the original article. It took me a while to get to the coevolution conclusion. You can watch my personal evolution and the development of my coevolution theory through my videos, recorded over the last three years. Once you understand the stepwise progression of the conditions – universally experienced by everyone afflicted with it, you recognize architecture. Architecture like that does not just appear; it is built. In our case, it evolved. So, coevolution is an easy conclusion. The final lock for me was the saline oscillations in the East Africa region. That finally explained the driving mechanism to have a symbiont on board that could help manage electrolyte balance [and a whole lot more].
If you want insight into my thinking process, it is fairly straightforward. For coevolution, I knew there were two organisms involved. I originally thought host and invader was the relationship between the two. I even started authoring Redacted Science with this narrative, and kept it throughout the book, even though I fully committed to the coevolution theory during the month or so it took me to write it. But, if you watch my videos, you will see how I started talking about it. There are over 100 videos, so far, but somewhere in there, I begin talking about coevolution. Why? Well, when your body has gone through a sequence of events foretold by an article you read over two and a half decades before which also documented the same journey of hundreds of other subjects in the first cohort, the full realization that this is a sequence defined by physiology sets in. The Article also described it as an inevitable process once initiated. Note, sequenced cascades happen in pure pathology too — the reason this one reads as design rather than decay is this cascade actually involves cycling of electrolytes and pH, and fundamental changes to physiology undocumented elsewhere in medical literature. So, if the process is inevitable, sequential, and not built around a linear decay, it is also natural or inherent. Thus, it is more accurate to say that it is by design. How does natural design happen? Evolution. So, it is evolutionary and involves two organisms, not one. Thus, it must be coevolutionary.
So, let’s talk about Terminal Onset Diabetes Insipidus with Candidiasis Majeure. In the early 20th century, a large cohort of individuals was treated for Central Diabetes Insipidus utilizing an injection of epinephrine. This treatment resolved their condition, but led to the Rube-Goldberg-like condition I mentioned above. This condition is unlike anything else in medicine. There is literally nothing like it. There are periods in the condition that are similar to other medical conditions (diabetes insipidus, Addison’s Disease, Cushing’s Disease, and more), but those periods are finite and end with a transition to another process/condition. The whole thing is centered around electrolytes. The Article mentioned how, after the initial conversion, the rest of the subject’s life was defined by moving electrolytes around. Lately, I’ve thought of that and realized it is basically defining a living biological battery of sorts, except this is much more complicated than an anode and a cathode. Here, the separators are cellular walls and electrolytic gradients.
But, perhaps the most fascinating things to think about, to me, are the implications of the transitions between the stages. After I used Ketoconazole to beat back the Candida albicans in the year following my conversion, my life was a lot closer to normal. I’m not saying there wasn’t weirdness, and that I didn’t have to beat it back again or suffer through things others did not, but people encountering me would not have known that I was doing so for 99% of that time (and that other 1% I made myself scarce). But 1% of the time is enough to make me vulnerable in a harsher period of history. I needed assistance motivating myself to eat and interact. Consider what that means for the coevolution.
Look at the entire process like a trip through the alphabet. An individual could get to say F on their own, but to get to G, they needed help from others. Remember, as this coevolution is occurring, the rest of the letters don’t even exist yet. So, for G to become a step in the process, assistance was required. Then, that person might continue to H. Eventually, the system developed further, and I, J, and K become steps, but to get to L, once again, assistance is needed. Not only is assistance needed, but communication is required, because a population of all ages going through this process would all be at different steps. They would need to know how to navigate their current step, prepare for the next one, and help others navigate their journey – all at the same time. Not only that, but what not to do is as important as what to do. This process has dependencies. For example, drinking too much fluid is a real concern. All of this means that the population within which this coevolution occurred was advanced enough to retain and distribute knowledge. If this were not possible, the process could not advance to the next letter. At a minimum, this requires a disciplined society that can communicate and support members who are temporarily under the weather. They would also need to be communal, not just a small band; this would necessitate organized social structures with elders who were respected and followed. Not listening or not respecting the elders would have been self-defeating. The elders were the furthest along in the process, so they had the most knowledge about it. This type of society would have done anything to prolong the life of the elders because they knew their life depended on the knowledge of the elders, along with another special ingredient – their flashes of insight.
What flashes of insight, you ask? The same type of insights that allowed me to piece this together. As I wrote Redacted Science, I knew that I was experiencing something physiologically profound. My state of mind was altered, my energy level was altered, and my level of insight was enhanced. I know it had to do with hormones and more, but I cannot explain exactly what caused it. It was unique, I felt driven, fearless, a little manic, but able to sleep just fine. I had ideas popping into my head constantly. It was a very creative and productive state of mind.
So, why did the first cohort of subjects from the early 20th century revert to this state of our evolution? The answer, it turns out, is relatively simple. The same process that sets the medical condition in motion also changes the way the heart beats. This was specifically discussed in the Article, and my own history backs it up. Your heart has two electrical nodes [interesting that once again we are back to energy, right?]. Changing the force of the current those nodes generate is all that is required to cause the heart to beat differently, such that the circulatory system has a lower incoming pressure to the heart than expected by causing suction due to a reconfiguration of cardiac function.
All of this advancement in evolution took a long time.
I estimate we coevolved for a minimum of 50,000 generations. Compare that to the 40 or so generations since Christianity was founded. This would obviously not be a simple coevolution. Yet, nothing in science really points to Candida albicans as that big of a deal. Why? It isn’t the why you would think.
They figured it out, and they decided not to tell anyone [and I tied it to nine chronic conditions]. The fact that you can no longer find the original research I read, combined with the knowledge of who was working in close proximity in the early 1960’s doing research into essentially every element of this condition just before they came out and said “Kill it” [don’t look at it too closely], those items raise the threshold to beyond a reasonable doubt. Suppression is why you cannot accept that 9 diseases are related, and also why I can.
Medicine is built around the assumption that you treat the individual. That base assumption is invalid once you know there is another organism integrated into every single system inside the individual, reacting to every stimulus and environmental change of the host. Thus, medicine is largely invalid. Their model is fundamentally flawed, and they know it [on some level, admittedly, the provider level is ignorant, but the upper echelons knew and somehow I doubt that is information they would allow to be completely forgotten, so someone still knows].
This has been going on for a long time. I’ve had three and a half years of almost continuous changes in my condition without ever having a medical diagnosis, and I’ve documented what they missed in my case studies. The labs they overlooked are glaring. What labs are designed to overlook becomes obvious. Why the tests are designed that way is one of the reasons you know that the system is well aware of everything I’ve documented.
Moving Forward
I have slowed down in my writing and even my log entries. That is not because I believe I am wrong [I know I’m right], it is because I have covered enough ground to make my case. Are all my theories right? I doubt it. Is the underlying science right – that we coevolved with Candida albicans for a very long period of time? Absolutely. There can be no other conclusion; it is only a matter of time before that science is revealed.
I have reached out to some researchers and actually corresponded with a few well-known people in their areas. The Framework is broad. Any engagement is likely to be limited to a subset of it, but all engagement is welcome.
There is plenty of ground yet to be covered, but others can take on those efforts. I will continue logging to Nostr, and doing small things, but I have been managing to enjoy life despite the obstacles of this point in the overall arc of this condition. I’ve been reading, watching documentaries, spending time with family, and performing work, while I document the shifts in my condition. At this point, the most important contribution I can make is to continue extending the Framework through my personal logs. I cannot enter the Centralized Institutional Medical System because I’m a square peg and they only know about round holes. So, I document and enjoy my time.
I think I’ll go and lie out by the pool, I never expected to see finished, and grab some sun.
Jim Craddock
